中华医学杂志（英文版）Issue(10)：1513-1517,5.
Lipoprotein glomerulopathy:clinical features and pathological characteristics in Chinese
Lipoprotein glomerulopathy:clinical features and pathological characteristics in Chinese
陈惠萍 1刘志红 1龚如军 1唐政 1曾彩虹 1朱茂艳 1王建平 1周虹 1黎磊石1
作者信息
- 1. Research Institute of Nephrology,Jinling Hospital,School of Medicine,Nanjing University,Nanjing 210002,China
- 折叠
摘要
Abstract
Background Lipoprotein glomerulopathy (LPG), once recognized as a rare glomerular disease, has been reported around the world in recent years. In this study, we reported 8 patients of LPG and aimed to explore the clinical features and pathological characteristics of LPG under light microscope, immunofluorescence staining, and electron microscope.Methods Clinical manifestations were recorded on the day of renal biopsy. Biochemical patterns of lipids and lipoproteins were detected by routine examination. Plasma concentrations of apo B and apo E were determined by radial immunodiffusion assays. Biopsy specimens were then processed for light microscopy, immunohistochemical staining for immunoglobulins and complement components, and electron microscopy. Glomerular deposition of apo A, B, and E were detected using monoclonal antibodies on cryostatic sections.Results All of the eight patients presented with edema, microscopic hematuria, severe proteinuria, anemia, and enlarged kidney size. Biochemical profiles revealed high levels of triglycerides, apo B, and apo E. We noted increments of glomerular size and lipoprotein thrombi occupying capillary lumina in the glomeruli of all patients. Immunofluorescence staining showed that the thrombi were strongly positive for apo A, B, and E. Granules and various sizes of vacuoles were observed in the thrombi under electron microscope.Conclusion Compared with previous reports on LPG in other countries, unique clinical and pathological features were found in this group of Chinese LPG patients.关键词
lipoprotein glomerulopathy/pathological characteristics/clinical featuresKey words
lipoprotein glomerulopathy/pathological characteristics/clinical features分类
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陈惠萍,刘志红,龚如军,唐政,曾彩虹,朱茂艳,王建平,周虹,黎磊石..Lipoprotein glomerulopathy:clinical features and pathological characteristics in Chinese[J].中华医学杂志（英文版）,2004,(10):1513-1517,5.
