山东医药2001，Vol.41Issue(4)：15-16,2.
P16蛋白在人脑胶质瘤中的表达
Expression of P16 protein in glioma
李卫国 1李新钢 2孔建新 2郭春3
作者信息
- 1. 烟台毓璜顶医院
- 2. 山东大学齐鲁医院
- 3. 烟台芝罘医院
- 折叠
摘要
Abstract
To observe the expression of P16 protein in human gliomas，theanti-P16 polyclonal antibody was applied to detect the expression of P16 protein in glioma cells by immunohistochemical method.The results showed that P16 pr otein was detected in plastic region of tumor cell.The frequency of positive exp ression of P16 protein in astrocytoge nic gliomas and ependymogenic gliomas wa s 42.9％ and 100％ respectively.The differ ence was significance（P＜0.025）in statist ic.The distribution of positive expressi on rate of P16 protein was different in different grade of gliomas.The differ ences were significant（P＜0.05）.This sugg ested that as the malignant degree o f gl ioma was raising， the expression rate of P16 protein in gliomas was decreasing. The deletions of P16 protein expressi on，e.g.the P16 gene homozygous deleti ons play an important role in malignant transformation of gliomas. The clinical results could be pre dicted by different expression levels of P16关键词
P16蛋白 胶质瘤 免疫组织化学分类
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李卫国,李新钢,孔建新,郭春..P16蛋白在人脑胶质瘤中的表达[J].山东医药,2001,41(4):15-16,2.
