西北国防医学杂志2001，Vol.22Issue(1)：15-17,3.
周围神经损伤对脊髓运动神经元NT－3表达的影响
The change of neurotrophin 3 in spinal motor neurons following sciatic nerve lesion in rats
石向群 1范明 2陆兵勋 2杨金升 1赵友岐 2汪泳1
作者信息
- 1. 兰州军区兰州总医院神经内科,
- 2. 军事医学科学院三所
- 折叠
摘要
Abstract
Objective:To study the change of neurotroph in 3(NT－3) in the spinal motor neuron and the association between it and the degree of degeneration and death in spinal motor neuron following sciatic nervele sion in the rats.Methods:The sciatic nerve lesion wa s induced with cutting and removing part of the sciatic nerve in the adult and 3 days of age rats.The rats were allowed to survive for 3,7,14,21,28 days.The ext ent of spinal motor neuron death and degeneration was examined,the level of NT－ 3 in spinal motor neuron were measured with image analysis.Results :The level of NT－3 in spinal motor neuron in suckling and adultr at groap was significant reduced following sciatic nerve lesion,and it was lowest in the second week after sciatic nerve lesion.The level of NT-3 in spinal mot or neuron in the 28th day following sciatic nerve lesion did not increase to it of the control.The change of spin al motor neuron death and degeneration was similar to the change of the level of NT－3.The level of NT－3 in spinal motor neuron in suckling rat was highter than it in adult rat. Conclusion:The level of NT－3 in spinal motor neurons would take change following sciatic nerve lesion,and the de ath and degeneration of spinal motor neuron may be induced by the peripheral ner ve lesion,The level of NT－3 in spinal motor neuron was negative with the extent of spinal motor neuron death and degeneration.关键词
神经损伤/周围神经/神经元分类
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石向群,范明,陆兵勋,杨金升,赵友岐,汪泳..周围神经损伤对脊髓运动神经元NT－3表达的影响[J].西北国防医学杂志,2001,22(1):15-17,3.
