中国现代医学杂志2004，Vol.14Issue(7)：15-17,22,4.
支气管哮喘病人嗜酸性粒细胞凋亡的研究
Investigation of eosinophil apoptosis in asthma patients
摘要
Abstract
Objective: To investigate the inhibition of eosinophil apoptosis in asthma patients. Methods: 30cases of asthma patients who were both in acute attack stage and in stable stage and 30 healthy men were received bronchofibroscopy to take the bronchoalveolar lavage fluid (BALF) . Apoptosis of eosinophil of BALF was investigated by TdT -mediated dutpnic end labeling (TUNEL). Results:The percentage of apoptotic eosinophil were (3.50+ 1.59)% in acute attack group and (5.53 +2.22)% in stable stage group of asthma patients. The percentage of apoptotic eosinophil was (6.90 + 3.27) % of healthy men group. The statistics difference in 3 groups was signification (P ＜ 0.001 ). Conclusions :There were inhibition of eosinophil apoptosis in acute attack of asthma patients. The inhibition of eosinophil apoptosis may be one of the important mechanism reasons of asthma. Methylprednisolone may promote eosinophil apoptosis in asthma patients.关键词
支气管哮喘/嗜酸性粒细胞/凋亡Key words
Asthma/Eosinophil/Apoptosis分类
医药卫生引用本文复制引用
韩守信,韩晓梅,吴晓梅,陈复辉,徐岩松..支气管哮喘病人嗜酸性粒细胞凋亡的研究[J].中国现代医学杂志,2004,14(7):15-17,22,4.基金项目
Supported by Natural Science Funds in Heilongjiang (D9918) （D9918）
