同济大学学报（医学版）2001，Vol.22Issue(1)：15-17,24,4.
Bcl-2蛋白与胃癌相关性的研究
A Correlation Study between Bel*.2 Protein Expression and Gastric Cancer
摘要
Abstract
Objective To study the expression and the roles of Bel*.2 protein in the carcinogenesis of gastric carcinoma. Methods The expression of protein encoded by Bel*.2 gene in 50 cases of gastric cancer and 10 normal gastric tissue by immunohistochemical staining was detected and compared according to Buke"s stages of tumors and precancerous lesions. Results The positive rates were 68.0%, 64.0%, 59.0% and 57.9% in advanced gastric cancers, gastric cancer in early stages, gastric cancers in early stage with intestinal metaplasia and dysplasia respectively, all being higher than that (20.0%) in normal gastric tissue. According to the degree of differentiation, high-differentiatd gastric cancer had a positive rate of 82.4% > moderate-differentiated gastric cancer(50.0%) > low-differentiated gastric cancer (17.6%). The extent of proliferative zone could be seen in the tissue of surrounding cancer tissue. The expression of Bel*.2 protein was strongly positive in proliferative cells and glands. Conclusion Bel*.2 protein is an important pro-oncogene and play an important role in the carcinogenesis.The expression of Bel*.2 protein in gastric carcinoma is associated with the degree of differentiation, precancerous lesion and proliferative cells. It suggests that Bel*.2 may lead to carcinogenesis either by inhibiting apoptosis or by inducing cell proliferation together with other genes.关键词
Bcl-2蛋白/胃肿瘤/免疫组织化学分类
医药卫生引用本文复制引用
裘莹,宋伯根,沈丽贤,赵桂芬..Bcl-2蛋白与胃癌相关性的研究[J].同济大学学报（医学版）,2001,22(1):15-17,24,4.
