中国临床康复2005，Vol.9Issue(41)：152-154,3.
大鼠颅脑损伤后心肌损害及血浆和心肌血管紧张素的变化
Myocardial damage and changes of plasma and myocardial angiotensin after craniocerebral injury in rats
摘要
Abstract
BACKGROUND: Craniocerebral injury can cause a series of visceral complications, among which cardiovascular complication is paid special attention.OBJECTIVE: To investigate the effects of craniocerebral injury on changes of circulatory and local angiotensin Ⅱ (Ang Ⅱ ) and local angiotensin Ⅱ receptor 1 (AT1) in the heart.DESIGN: Randomized controlled experiment taking animals as subjects.SETTING: Beijing Tiantan Hospital, and the College of Basic Medicine,Capital University of Medical Sciences.MATERIALS: The experiment was conducted at the Central Laboratory of Capital University of Medical Sciences and the Central Laboratory of Beijing Tiantan Hospital from 2003 to 2004. Totally 40 healthy male Wistar rats were divided randomly into craniocerebral injury group and control group with 20 in each group.METHODS: Rats in craniocerebral injury group were treated with weightdrop method to establish the model of craniocerebral injury, while rats in control group received no impact. Twenty-four hours after hitting, 10 rats in each group were selected to assay their Ang Ⅱ and AT1; the other 10 in each group were selected to observe their myocardial forms.myocardium of rats assayed with light microscope after hematoxylin-eosin staining and transmission electron microscope.It was significantly higher in craniocerebral injury group than in control ity: It was obviously higher in craniocerebral injury group than in control Ⅱ and AT1: The area of positive reactant and gray value in craniocerebral toxylin-eosin staining: Strong acidophil staining was found on myocardial cellular plasma in craniocerebral injury group. The results showed that cytoplasm shrank obviously; muscle fiber broke, decreased or disappeared.Focal hydropic degeneration, lysis or necrosis was observed in myocardium.Ultrastructural pathological observation revealed pathological damage of myocardium.CONCLUSION: Craniocerebral injury in rats can cause myocardial damage, and changes of angiotensin system may be one of the factors.关键词
颅脑损伤/心肌/血管紧张素Ⅱ/受体,血管紧张素分类
医药卫生引用本文复制引用
郭彩霞,杜凤和,张立克,徐秀英,陈瑞芬,孙异临,何士大,王淑敏..大鼠颅脑损伤后心肌损害及血浆和心肌血管紧张素的变化[J].中国临床康复,2005,9(41):152-154,3.基金项目
首都医学发展科研基金(2002-2025) Capital Medical Developing Foundation, No. 2002-2025 （2002-2025）
