南京医科大学学报（英文版）2005，Vol.19Issue(3)：152-155,4.
Quantitative MR application in depression model of rats: a preliminary study
Quantitative MR application in depression model of rats: a preliminary study
Wei Wang 1Wenxun Li 2Fang Fang 3Hao Lei 3Xiaoping Yin 1Jianpin Qi 1Baiseng Wang 1Chengyuan Wang1
作者信息
- 1. Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- 2. Beijing University of Chinese Medicine, Beijing 100089, China
- 3. Wuhan Institute of Physics and Mathematics, the Chinese Academy Science, Wuhan 430032, China
- 折叠
摘要
Abstract
Objective: To investigate findings and value of quantitative MR in depression model of rats. Methods: Twenty male SD rats were divided into model group and control group randomly (10 rats in each group). The depression model of rats was erected by separation and chronic unpredictable stress. The behavior of rat was detected by open-field test and sucrose consumption. The MR images of brain tissues were produced in vivo rats with T2-and diffusion-weighted imaging. The changes of body weight and behavior score and thevalues of T2 and ADC of ROIs were compared between the two groups. Histological verification of hippocampal neuron damage was alsoperformed under ultramicrosopy. Results: Compared with the control group, T2 values in hippocampus prolonged 5.5 % ( P ＜ 0.05),ADC values in hippocampus and in temporal lobe cortex decreased 11.7 % and 10.9% (P ＜ 0.01)respectively in the model group. Histo-logic data confirmed severe neuronal damage in the hippocampus of the model group. Conclusion: This study capitalized on diffusion-weighted imaging as a sensitive technique for the identification of neuronal damage in depression and it provides an experimental evidence ofMRI in depression investigation and clinical application.关键词
depression/rat/magnetic resonance imaging/diffusionKey words
depression/rat/magnetic resonance imaging/diffusion分类
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Wei Wang,Wenxun Li,Fang Fang,Hao Lei,Xiaoping Yin,Jianpin Qi,Baiseng Wang,Chengyuan Wang..Quantitative MR application in depression model of rats: a preliminary study[J].南京医科大学学报（英文版）,2005,19(3):152-155,4.
