中国全科医学2009，Vol.12Issue(16)：1530-1531,2.
碱性成纤维细胞生长因子-2在Graves眼病发病机制中的作用
The Role of Basic Fibroblast Growth Factor-2 in Pathogenesis of Graves′ Ophthalmopathy
摘要
Abstract
Objective To investigate the role of basic fibroblast growth factor-2(bFGF-2)in the pathogenesis of Graves′ophthalmopathy (GO).Methods Twenty GO patients(research group) and 20 with simple hyperthyroidism without eye symptoms(control group) were enrolled to determine serum bFGF-2 and hyaluronic acid(HA) levels.The results were compared to find out the factors related to bFGF-2.Results The mean HA level was significantly higher in research group(551±316 ng/ml) than in control(351±249 ng/ml) (P＜0.05);the bFGF-2 level increased significantly in research group(98±28 pg/ml) as compared with control (77±20 pg/ml) (P＜0.05).Spearman regression analysis showed that HA level and clinical activity score(CAS) were significantly correlated with bFGF-2 level(P＜0.05).Conclusion The bFGF-2 level in peripheral blood increases significantly,suggesting that bFGF-2,an indicator determining GO activity,may play an important role in GO pathogenesis.关键词
Graves眼病/成纤维细胞生长因子,碱性/透明质酸Key words
Graves′ophthalmopathy/Fibroblast growth factor-2,basic/Hyaluronic acid分类
医药卫生引用本文复制引用
叶小珍,王坚,胡兰萍,顾萍,李洁,邵加庆,王燕燕..碱性成纤维细胞生长因子-2在Graves眼病发病机制中的作用[J].中国全科医学,2009,12(16):1530-1531,2.基金项目
江苏省自然科学基金资助项目(BK2007574) （BK2007574）
南京军区南京总医院青年基金资助项目(Q2008010) （Q2008010）
