首页|期刊导航|中华医学杂志（英文版）|Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit
中华医学杂志（英文版）2003，Vol.116Issue(10)：1544-1548,5.
Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit
Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit
摘要
Abstract
Objective To explore a new method for the therapy of avascular necrosis of the femoral head.Methods The recombinant plasmid pCD-hVEGF165 was mixed with collagen and was implanted in the necrotic femoral head. The expression of vascular endothelial growth factor (VEGF) was examined by RNA dot hybridization and immunohistochemical techniques. Repair of the femoral head was observed by histological and histomorphometric analysis.Results The expression of VEGF was detected in the femoral head transfected with the VEGF gene. The femoral head transfected with the VEGF gene showed a significant increase in angiogenesis 2 and 4 weeks after gene transfection and a significant increase in bone formation 6 and 8 weeks after gene transfection on histomorphometric analysis (P<0.01).Conclusions Transfection of the VEGF gene enhances bone tissue angiogenesis. Repair of osteonecrosis could be accelerated accordingly, thus providing a potential method for therapy of osteonecrosis.关键词
vascular endothelial growth factor/gene transfection/avascular necrosis/femoral headKey words
vascular endothelial growth factor/gene transfection/avascular necrosis/femoral head分类
医药卫生引用本文复制引用
杨操,杨述华,杜靖远,李进,许伟华,熊宇芳..Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit[J].中华医学杂志（英文版）,2003,116(10):1544-1548,5.基金项目
This study was supported by a grant from the National Natural Science Foundation of China (No. 30170945). （No. 30170945）
