中华医学杂志（英文版）2003，Vol.116Issue(10)：1553-1556,4.
Protein kinase C in proliferation and infiltration of eosinophils in nasal polyp
Protein kinase C in proliferation and infiltration of eosinophils in nasal polyp
李美华 1董震 1杨占泉 1白蕴红2
作者信息
- 1. Department of ORP-HNS, China-Japan Union Hospital, Jilin University, Changchun 130031, China
- 2. Department of Neuroscience, Dentistry of New Jersey University of Medicine, Newark 07103, USA
- 折叠
摘要
Abstract
Objective To explore the significance of protein kinase C (PKC) in proliferation and infiltration of eosinophils in nasal polyps. Results In eosinophils, the positive cell expressive rates of Bcl-2 mRNA and its protein were significantly higher in the group with nasal polyps than in the ITMT group (P<0.01). Although the positive cell expressive rate of Bax mRNA and associated protein were a little higher in the group with nasal polyp tissues than in the ITMT group, the difference was not significant (P>0.05). There was PKC expression in the eosinophils of 26 cases of nasal polyps, but occasional PKC expression in 7 of 20 ITMT cases. In the two groups, PKC positive cell expression was significantly different, and the expression of PKC and bcl-2 mRNA as well as associated protein in eosinophils of nasal polyps showed a remarkably positive relationship (r1=0.0875, r2=0.0823, P<0.01).Conclusions Increased PKC expression in eosinophils of nasal polyp tissues is closely associated with apoptosis inhibition, and it is presumed that eosinophil apoptosis inhibition in nasal polyp tissues is obtained by activation of the PKC signal transduction pathway.关键词
protein kinase C/nasal polyp/eosinophils/in situ hybridization/immunohistochemistryKey words
protein kinase C/nasal polyp/eosinophils/in situ hybridization/immunohistochemistry分类
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李美华,董震,杨占泉,白蕴红..Protein kinase C in proliferation and infiltration of eosinophils in nasal polyp[J].中华医学杂志（英文版）,2003,116(10):1553-1556,4.
