中国临床康复2004，Vol.8Issue(8)：1555-1557,3.
失神经支配肌肉感觉神经营养活性的研究
Study on the sense neurotrophism of denervated muscles
王敬博 1罗永湘 2刘文革2
作者信息
- 1. 天津骨科医院急救创伤科,天津市,300211
- 2. 华中科技大学同济医学院附属同济医院矫形外科,湖北省武汉市,430030
- 折叠
摘要
Abstract
BACKGROUND:It was proved that there was neurotrophism in the muscles, but there was no more knowledge on the neurotrophic factors and the neurotrophism of the denervated muscles. OBJECTIVE:To clarify the character of nerve growth factor(NGF) in the denervated red and white muscles and the relationship between the amount of NGF and sensitive neurotrophism of denervated red and white muscles. DESIGN: Non-randomized control trial. SETTING and PARTICIPANTS:Forty Wister rats,weighing 200-250g were provided by the Animal Center of the Tongji Medical College in the Huazhong University of Science and Technology. INTERVENTION:The model of the denervated gastrocnemius and soleus was made by clipping the sciatic nerve . MAIN OUTCOME MEASURE:The immunohistochermistry was taken to measure the amount of NGF in muscles ,and the neurotrophism of extracts of muscles was tested with culture of dorsal root ganglions at the time of the lst, 3rd, 7th and 14th day after injury. RESULTS: The amount of NGF in denervated gastrocnemius(GAS) and soleus(SOL) decreased, especially in SOL. The neurotrophism of the extracts of the two kinds of denervated muscles promoted in the 1st week. CONCLUSION:The peripheral nervous injury causes changes of NGF level of their innervated muscle in a time-dependent manner and there exists difference between changes of NGF in white and red muscles.Yet,the neurotrophic activity of the denervated muscle results from not only NGF, but also the integration of multiple neurotrophic factors. 关键词
肌,骨骼/去神经支配/神经营养因子分类
医药卫生引用本文复制引用
王敬博,罗永湘,刘文革..失神经支配肌肉感觉神经营养活性的研究[J].中国临床康复,2004,8(8):1555-1557,3.
