现代妇产科进展2008，Vol.17Issue(2)：157-160,4.
Risk factors for atypical endometrial hyperplasia in infertile women:possible association with polycystic ovarv syndrome
Risk factors for atypical endometrial hyperplasia in infertile women:possible association with polycystic ovarv syndrome
Lu Qun 1Shen Huan 1Tian Li 1Zhu Sainan 2Chen Xi1
作者信息
- 1. Reproductive Medical Center,People's Hospital,Peking University,Beijing 100044
- 2. Statistics Department,The First Hospital of Peking University
- 折叠
摘要
Abstract
Objective:Endometrial hyperplasia is considered as a precursor of endometrial carcinoma,in which oncogenic potential is low in hyperplasia without atypia,but high in a-typical hyperplasia.The objective of this study was to identify the risk factors for atypical endo-metrial hyperplasia in infertile women.Methods:Fifty four infertile women with endometrial hy-perplasia,which were selected from a large cohort of 2 098 women who desired for the future childbearing in our center,were diagnosed by hysteroscopy with directed biopsies or dilation and curettage(D&C),including 44 with hyperplasia without atypia,10 with atypical hyperplasia.Clinical characteristics were recorded in terms of age,body mass index(BMI),parity,insulin resistance,polycystic ovary syndrome(PCOS).Statistical comparison was made between women with hyperplasia without atypia and atypical hyperplasia.Logistic regression analysis Was em-ployed to assess the contribution of PCOS,obesity and insulin resistance to atypical hyperplasia.Results:The incidence of endometrial hyperplasia in infertile women Was 2.57%(54/2098),which included 1 0 women(0.48%)were diagnosed as atypical hyperplasia.PCOS in women with atypical hyperplasia(70%,7/10)was significantly higher than those of hyperplasia with-out atypia(27.27%,12/44).Stepwise regression analysis showed that PCOS contributed maximally to atypical endometrial hyperplasia in infertile women.Conclusion:PCOS is an independent risk factor for atypical endometrial hyperplasia in women with infertility.The infertile women with PCOS are at an increased risk for atypical endometrial hyperplasia and endometrial cancer.
关键词
Endometrial hyperplasia/Polycystic ovary syndrome/Obesity/Insulin resistanceKey words
Endometrial hyperplasia/Polycystic ovary syndrome/Obesity/Insulin resistance分类
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Lu Qun,Shen Huan,Tian Li,Zhu Sainan,Chen Xi..Risk factors for atypical endometrial hyperplasia in infertile women:possible association with polycystic ovarv syndrome[J].现代妇产科进展,2008,17(2):157-160,4.
