中国临床药理学与治疗学2004，Vol.9Issue(2)：157-161,5.
不同剂量蛇毒抗高凝状态酶对小鼠肝癌H22生长作用的实验研究
Experimental study on inhibitory effect of antihypercoagulability state enzyme of snake venom in different dosages in mice with Hepatocarcinoma
摘要
Abstract
AIM:To research the inhibitory effect of antihypercoagulability state enzyme (AHCSE) of snake venom in different dosages in mice with Hepatocarcinoma. METHODS: Hepatic cancer H22 model in mice was performed through subcutaneous inoculation of Right-Sidedness Axilla of BALB/C mice. Different dosages of AHCSE (1, 2, and 4 mg*kg-1) were injected via abdominal cavity everyday for 10 days. When the tumor grew to 10 mm3, the weight, volume, percent inhibition of tumor, spleen index and the number and the component of white blood cells were observed. RESULTS: The middle and high dosages of AHCSE had obvious inhibition in hepatic cancer. It showed a significant dose-dependent relation in the effects of AHCSE on neoplastic weight, neoplastic volume and splenic index. There was a linear regression between the number of leucocytes and the splenic index. CONCLUSION: AHCSE of 2-4 mg*kg-1 has significant inhibitory effect on tumor, and shows dose-related effect in mice with Hepatocarcinoma. Its mechanism is presumably associated with activating immune system.关键词
蛇毒抗高凝状态酶/H22肝癌/抗肿瘤Key words
antihypercoagulability state enzyme of snake venom/hepatic cancer/antitumor分类
医药卫生引用本文复制引用
芮景,程明荣,徐永强,文尚武..不同剂量蛇毒抗高凝状态酶对小鼠肝癌H22生长作用的实验研究[J].中国临床药理学与治疗学,2004,9(2):157-161,5.基金项目
Project supported by the Scientific Research Foundation of the Anhui Committee of Education(№2001kj255) （№2001kj255）
