首页|期刊导航|南京医科大学学报(英文版)|HERG K+ channels expression in gastric cancers and analysis of its regulation in tumor cell proliferation and apoptosis
南京医科大学学报(英文版)2009，Vol.23Issue(3)：157-162,6.
HERG K+ channels expression in gastric cancers and analysis of its regulation in tumor cell proliferation and apoptosis
HERG K+ channels expression in gastric cancers and analysis of its regulation in tumor cell proliferation and apoptosis
摘要
Abstract
Objective: To investigate the expression of herg 1 gene in tumor tissues from gastric carcinomas and gastric carcinoma cell lines, and study the relationship between HERG K+ channel expressions and tumor cell proliferation and apoptosis. Methods: RT-PCR and PCR assays were used to detect the expression of herg 1 gene in 64 gastric carcinomas and the gastric cancer cell line SGC-7901. Blocking the HERG K+ channels was used to evaluate their effects on tumor cell proliferation and apoptosis. Results:The statistically significant expression of herg 1 gene was detected in all the gastric cancers and SGC-7901 cells, but not in normal tissues. The HERG K+ channel blocker, E-4031, increased the cell population in G0/G1 (P＜0.05) and the number of apoptotic tumor cells(P＜0.05). Conclusion: HERG K+ channels were expressed in all gastric carcinomas tested and these channels appear to modulate tumor cell proliferation and apoptosis.关键词
gastric carcinoma / HERG K+ channel/ herg 1 gene/ proliferation/ apoptosisKey words
gastric carcinoma / HERG K+ channel/ herg 1 gene/ proliferation/ apoptosis分类
医药卫生引用本文复制引用
Qing Lü,Huiyu Li,Xiaoming Lu,Guobin Wang..HERG K+ channels expression in gastric cancers and analysis of its regulation in tumor cell proliferation and apoptosis[J].南京医科大学学报(英文版),2009,23(3):157-162,6.基金项目
This work was supported by a grant from the Natural Science Foundation of China(30772128). （30772128）
