广东药学院学报2000，Vol.16Issue(1)：1-6,6.
tRNAHis/GUG识别特性的分子力学模拟
Molecular Mechanics Simulation of Recognition Identity of tRNAHis/ GUG
姚立新 1曹槐 2刘次全3
作者信息
- 1. 广东药学院药物研究所,广东广州,510224
- 2. 云南大学现代生物学研究中心
- 3. 中国科学院昆明动物研究所细胞与分子进化重点实验室
- 折叠
摘要
Abstract
A group of nucleic acid sequences retrieved from experiment was analyzed based o n molecular mechanics simulation method to prove tRNA recognition identity that was derived from parts of tRNAHis/GUG sequence. A simplified molecular mod el of nucleic acid sequences with cage-like water molecules and Mg2+ ions was co nstruc ted. Based upon the primary analyses of the optimized molecular models, such as conformation parameters, bonding propensities, and energies of optimized models, etc., the recognition identity of tRNAHis/GUG was probed and the result w as s imilar to experiment-determined ones. Some problems, such as stem-loop structure (hair-pin structure), the impacts of charged metal ions (Mg2+) and H2O molecule s on the stability of nucleic acid sequences, non-Watson-Crick base pairing (i.e . U·U/G·U base pairing), and stabilizing influence of the ″cage-like″ solven t-solvent and solvent-solute bonds were also discussed.关键词
计算机辅助分子建模(CAMM)/识别特性/tRNAHis/GUG/分子力学/氢键网络Key words
computer-aided molecular modeling (CAMM)/tRNAHis/GUG/recognition identity/molecular mechanics/hydrogen-bond network分类
天文与地球科学引用本文复制引用
姚立新,曹槐,刘次全..tRNAHis/GUG识别特性的分子力学模拟[J].广东药学院学报,2000,16(1):1-6,6.
