中华医学杂志（英文版）2002，Vol.115Issue(11)：1603-1607,5.
静脉注射三磷酸腺苷99mTc-MIBI心肌灌注显像诊断冠心病的评价
Evaluation of 99m Tc-MIBI myocardial perfusion imaging with intravenous infusion of adenosine triphosphate in diagnosis of coronary artery disease
摘要
Abstract
Objective To evaluate the feasibility, safety and diagnostic accuracy of pharmacologic stress of 99m Technetium-MIBI single-photon emission computed tomography (SPECT) with intravenous adenosine triphosphate (ATP) in patients with suspected coronary artery disease.Methods The study group included 263 patients who were suspected of having coronary artery disease. All patients underwent 99m Tc-MIBI myocardial perfusion imaging with ATP infusion (0.16 mg/kg body weight per min for 5 min). 20 mCi of 99m Tc-MIBI were injected 3 minutes after the start of ATP infusion. Myocardial SPECT images were obtained 60 minutes later. Then, two days later, 20 mCi of 99m Tc-MIBI were administered at rest and myocardial SPECT was repeated. 51 patients also underwent coronary angiography within two weeks for evaluation of sensitivity and specificity of ATP-myocardial perfusion imaging in detection of coronary artery disease. The occurrence of cardiac and non-cardiac adverse effects was carefully monitored during and after intravenous ATP infusion.Results The ATP infusion protocol was completed in all patients. Although 59% of the patients had various kinds of adverse effects, most of them were mild. No patient required aminophyline. The most severe adverse effect was second degree type Ⅱ atria-ventricular block (4/263), but all events were transient. The sensitivity and specificity of ATP-myocardial perfusion imaging were 97% and 82%, respectively.Conclusions It is shown that 99m Technetium-MIBI SPECT with intravenous ATP is a safe and feasible technique for detecting coronary artery disease in patients unable to perform the exercise test.关键词
三磷酸腺苷/冠心病/心肌灌注显像/单光子断层显像/药物试验Key words
adenosine triphosphate/coronary artery disease/myocardial perfusion imaging/single-photon emission computed tomography/pharmacologic stress分类
医药卫生引用本文复制引用
何青,姚稚明,于雪,屈婉莹,孙福成,季福绥,许锋,钱贻简..静脉注射三磷酸腺苷99mTc-MIBI心肌灌注显像诊断冠心病的评价[J].中华医学杂志（英文版）,2002,115(11):1603-1607,5.基金项目
This study was supported by the Ministry of Health (No. 003). （No. 003）
