中国药房2009，Vol.20Issue(21)：1604-1606,3.
复方去甲斑蝥素胃内滞留漂浮型缓释片在犬体内的药动学研究
Pharmacokinetics of Compound Norcantharidin Sustained Release Tablets Remaining - floating in Stomach in Dogs
摘要
Abstract
OBJECTIVE: To study the pharmacokinetic process of Compound noreantharidin sustained release tablets re-maining- floating in stomach in dogs. METHODS: Plasma drug concentration was determined by HPLC. By two- period crossover experiment design, 8 healthy beagle dogs were assigned to receive Compound norcantharidin sustained release tablets remaining-floating in stomach or common norcantharidin tablets, with pharrnacokinetic parameters determined. RESULTS: The pharrnacokinetics of both Compound norcantharidin remaining - floating sustained release tablets and common norcan-tharidin tablets fitted two-compartment model, their pharmacokinetic parameters were stated as follows: tmax:(3.01 ± 0.02) h vs.(2.02±0.03) h; Cmax: (58.3±4.4) μg·mL-1 vs.(56.6±3.90) μg·mL-1; AUCo～24: (536.4±33.8) μg·h·L-1 vs. (232.50 ± 10.63) μg·h·L-1; MRT: (8.3 ± 0.4) h vs. (3.3 ± 0.05) h. The relative bioavailability of Compound norcantharidin remaining- floating sustained release tablets was 230.71%. CONCLUSION: The Remaining- floating (in stomach) property of Compound norcantharidin sustained release tablets contributed to higher bioavailability as compared with the common tablets of norcantharidin.关键词
去甲斑蝥素/胃内滞留漂浮型缓释片/高效液相色谱法/药动学Key words
Norcantharidin/Remaining- floating sustained release tablets/HPLC/Pharmacokinetics分类
医药卫生引用本文复制引用
李洪斌,王艳萍,赵楠,刘福强,刘莹,崔海珍..复方去甲斑蝥素胃内滞留漂浮型缓释片在犬体内的药动学研究[J].中国药房,2009,20(21):1604-1606,3.基金项目
国家自然科学基金资助项目(30672672) （30672672）
