中国现代医学杂志2006，Vol.16Issue(11)：1606-1609,1613,5.
VEGF-C的表达与食管鳞癌淋巴转移及预后的关系
VEGF-C expression correlates with lymphatic metastasis and prognosis in esophageal squamous cell carcinoma
摘要
Abstract
[Objective] To investigate the expression of vascular endothelial growth factor-C (VEGF-C) in esophageal squamous cell carcinoma (ESCC), and the relationship between its expression and the lymphatic metastasis and prognosis. [Methods] Immunohistochemical method was used to examine the expression of VEGF-C in 72cases of the ESCC and adjacent normal esophageal mucosa, and the percentage of the cells positively stained with VEGF-C antibody was calculated with a computer-aided microscopic image analysis system. [Results] VEGF-C antigen was not expressed in normal esophageal mucosa but detected in 28 of 72 (38.9%) neoplastic esophageal lesions. The expression of VEGF-C antigen was significantly associated with the depth of tumor invasion (χ2=10.77, P ＜0.01) and lymph node metastasis(χ2=10.98, P ＜0.01), but not with the patients' age, tumor size or differentiation (P ＞0.05). The overall survival rate of the patients with positive VEGF-C expression was significantly lower than that of the patients without VEGF-C expression (χ2=11.16, P ＜0.01). [Conclusion] The expression of VEGF-C in ESCC can promote tumor lymphatic metastasis, and it may serve as a risk factor indicating a poor prognosis of ESCC.关键词
食管肿瘤/血管内皮生长因子C/淋巴转移/预后Key words
esophageal neoplasm/VEGF-C/lymphatic metastasis/prognosis分类
医药卫生引用本文复制引用
逄小红,田铧,吕伯实,葛兆茹,李跃,张凤鸣..VEGF-C的表达与食管鳞癌淋巴转移及预后的关系[J].中国现代医学杂志,2006,16(11):1606-1609,1613,5.基金项目
Sustentation fund: This task was supplied by Shandong Natural Science Fund Item (No. Y2000C12) （No. Y2000C12）
