中国药理学与毒理学杂志2004，Vol.18Issue(3)：161-165,5.
灯盏花素对大鼠局灶性脑缺血再灌注后脑水肿和中性粒细胞浸润的影响
Effect of breviscapine on brain edema and neutrophil infiltration induced by focal cerebral ischemia and reperfusion in rats
何蔚 1刘奕明 2陈汇 2曾繁典2
作者信息
- 1. 赣南医学院药理学教研室, 江西 赣州 341000
- 2. 华中科技大学同济医学院药理学系临床药理研究所, 湖北 武汉 430030
- 折叠
摘要
Abstract
AIM To investigate whether breviscapine attenuates brain edema and neutrophil infiltration and inhibiton ICAM-1 expression in the cerebral ischemia-reperfusion rats. METHODS Focal cerebral ischemia-reperfusion model in rats were made by transient occlusion of the middle cerebral artery for 2 h followed by 24 h reperfusion. Breviscapine 50 and 75 mg*kg-1 were administered ip at 1 h and repeated at 22 h after reperfusion. Twenty-four hours later, brain edema, neutrophil infiltration and the expression of intercellular adhesion molecule-1(ICAM-1) were measured with dry-wet weight, myeloperoxidase(MPO) activity, and immunohistochemistry, respectively. RESULTS After ischemia reperfusion, brain water content was obviously increased, MPO activity and the expression of ICAM-1 in the ischemic hemisphere cortex of MCA area and caudate putamen were markedly increased. Treatment with breviscapine 50 and 75 mg*kg-1 reduced brain edema, inhibited MPO activity and the expression of ICAM-1. CONCLUSION Breviscapine attenuated brain edema and neutrophil infiltration after cerebral ischemia reperfusion.关键词
灯盏花素/脑缺血/脑水肿/中性粒细胞/细胞间黏附分子-1Key words
breviscapine/cerebral ischemia/brain edema/neutrophils/intercellular adhesion molecule-1分类
医药卫生引用本文复制引用
何蔚,刘奕明,陈汇,曾繁典..灯盏花素对大鼠局灶性脑缺血再灌注后脑水肿和中性粒细胞浸润的影响[J].中国药理学与毒理学杂志,2004,18(3):161-165,5.
