中国药房2009，Vol.20Issue(21)：1616-1617,2.
粉防己碱缓释凝胶微丸在犬体内的药动学研究
Pharmacokinetics of Tetrandrine Alginate Calcium Sustained Release Gel Pellets in Dogs
马燕 1葛月宾 2关世侠 1李卫中 3郭委1
作者信息
- 1. 广州中医药大学中药学院,广州市,510405
- 2. 中南民族大学生命科学学院药学系/民族药物研究所,武汉市,430074
- 3. 广东百澳药业有限公司,开平市,529339
- 折叠
摘要
Abstract
OBJECTIVE: To study the pharmacokinetics of tetrandrine(TET) sustained release gel pellets in dogs. METHODS: The dogs were assigned to receive single oral dose of sustained release gel pellets or common tetrandrine alginate calcium tablets by crossover self - control design. Plasma concentrations of tetrandrine alginate calcium were determined by RP-HPLC and the pharmacokinetic parameters were computed with 3P97 pharmacokinetic software. RESULTS: The tmax L-1 respectively.the relative bioavailability is(106.13±14.41)% .The pharmacokinetics in vivo was in line with one- com-partment first order absorption process. There existed a good correlation between release in vitro and absorption in vivo(r = 0.979 8) .CONCLUSION: Compared with the common TET tablets, TET sustained release gel pellets had smooth concentra-tion and significantly prolonged release, meeting the expected delayed release efficacy.关键词
粉防己碱缓释凝胶微丸/药动学/体内外相关性Key words
Tetrandrine sustained release gel pellets/Pharmacokinetics/Correlation between in vitro (release) and in vivo分类
医药卫生引用本文复制引用
马燕,葛月宾,关世侠,李卫中,郭委..粉防己碱缓释凝胶微丸在犬体内的药动学研究[J].中国药房,2009,20(21):1616-1617,2.
