中国病理生理杂志2001，Vol.17Issue(1)：16-18,3.
β-淀粉样蛋白对D-半乳糖致衰大鼠行为及海马SOD活性和MDA含量的影响
The effect of β-amyloid protein on the behaviors and SOD activity and MDA content of hippocampus in D-galactose-induced aging rats
摘要
Abstract
AIM: To study the effect of β-amyloid protein (β-AP) andD-galactose(D-gal) on learning-memory and SOD activity and MDA content of hippocampus in rats. METHODS: The behaviors of rats were measured by using open field, Y-maze and one-trial passive avoidance response, and the content of SOD and MDA were measured. RESULTS: In the D-gal and D-gal+β-AP group rats, the spontaneous activities and responses to novel environment in the open field were significantly decreased, and the abilities of learning-memory were remarkably attenuated, the content of SOD decreased and MDA content increased markedly in hippocampus (P＜0.05 or P＜0.01 compared with N group). CONCLUSION: The combination of β-AP and D-gal enhanced the damage induced by free radical in hippocampus and decreased the learning-memory ability in rats.关键词
淀粉样β蛋白/阿尔茨海默病/衰老/学习/记忆分类
医药卫生引用本文复制引用
李亚,秦海强,陈启盛..β-淀粉样蛋白对D-半乳糖致衰大鼠行为及海马SOD活性和MDA含量的影响[J].中国病理生理杂志,2001,17(1):16-18,3.基金项目
江苏省重点学科联建重点项目(No.9707) （No.9707）
