中国药房2009，Vol.20Issue(21)：1618-1619,2.
小檗碱对四氯化碳致小鼠急性肝损伤的保护作用研究
Protective Effect of Berberine on CCl4- induced Acute Liver Injury in Mice
李大庆 1吴明均1
作者信息
- 1. 遵义医学院附属口腔医院药剂科,遵义市,563000
- 折叠
摘要
Abstract
OBJECTIVE: To investigate the protective effect of berberine on CCl4- induced acute liver injury in mice. METHODS: Kunming mice were included and equally divided into 6 groups: normal group, model group, berberine groups transaminase (AST) in serum, activities of superoxidase (SOD) and malondialdehyde (MDA) content in liver homogenate were measured. RESULTS: In Berberine- treated groups compared the model group, serum ALT level and AST activity decreased significantly (P < 0.05 or P < 0.01), SOD activity ehanced(P < 0.05 or P < 0.01)while MDA content in hepatic tissue decreased (P < 0.05 or P < 0.01) .CONCLUSION: Berberine has protective effect on rats against CCh-induced acute liver injury, and the mechanism may be related to the enhanced anti -oxidation ability of mice.关键词
小檗碱/肝损伤/丙氨酸氨基转移酶/天冬氨酸氨基转移酶/超氧化物歧化酶/丙二醛Key words
Berberine/Liver injury/ALT/AST/SOD/MDA分类
医药卫生引用本文复制引用
李大庆,吴明均..小檗碱对四氯化碳致小鼠急性肝损伤的保护作用研究[J].中国药房,2009,20(21):1618-1619,2.
