中国药房2009，Vol.20Issue(21)：1620-1621,2.
丹皮酚在小鼠血浆和脑组织中的分布研究
Distribution of Paeonol in Plasma and Brain Tissue of Mice
陈群 1李士敏2
作者信息
- 1. 宁波天一职业技术学院,宁波市,315100
- 2. 浙江大学分析测试中心,杭州市,310029
- 折叠
摘要
Abstract
OBJECTIVE: To study the distribution characteristics of paeonol in the plasma and brain tissue of mice. METHODS: The concentrations of paeonol in the plasma and brain tissue of mice were determined by GC - MS and the pharmacokinetic parameters of paeonol calculated with 3P97 software were compared and evaluated. RESULTS: The main pharmacokinetic parameters of paeonol in the plasma and the brain were as follows: Ka: (99.3 h-1 vs 18.22 h-1) ; t1/2α: (0.04 h from plasma, and it had difficulty in passing through the blood-brain barrier but it has long retention time in brain tissue.关键词
丹皮酚/血浆/脑组织/药动学参数Key words
Paeonol/Plasma/Brain tissue/Pharmacokinetic parameters分类
医药卫生引用本文复制引用
陈群,李士敏..丹皮酚在小鼠血浆和脑组织中的分布研究[J].中国药房,2009,20(21):1620-1621,2.
