中华医学杂志（英文版）2002，Vol.115Issue(11)：1620-1623,4.
低分子量肝素和肾上腺糖皮质激素对阵发性睡眠性血红蛋白尿症患者红细胞体外溶血抑制作用的研究
Inhibiting effects of low-molecular weight heparin and adrenocortical hormone on hemolysis of red cells in patients with paroxysmal nocturnal hemoglobinuria in vitro
赵明峰 1邵宗鸿 1刘鸿 1曹铮 1田鹏 1付蓉 1施均 1何广胜 1白洁 1杨天楹1
作者信息
- 1. 中国医学科学院中国协和医科大学血液学研究所血液病医院,天津,300020
- 折叠
摘要
Abstract
Objective To study the effects of low-molecular weight heparin (LMWH) and adrenocortical hormone (dexamethasone) on the hemolysis of red cells of patients with paroxysmal nocturnal hemoglobinuria (PNH) in vitro. Methods Using Ham's test and micro-complement lysis sensitive test (mCLST), the changes in hemolysis of red cells from 6 typical PNH cases were examined after adding LMWH and dexamethasone in different concentrations into the test solution in vitro. The effects of LMWH and dexamethasone on the coagulation of the tested blood samples were also studied using the activated partial thromboplastin time (APTT) test. Conclusions Both LMWH and dexamethasone could inhibit hemolysis in PNH, and they showed a synergistic effect. Their mechanisms of inhibiting hemolysis differed from each other. Furthermore, a tolerable dose of LMWH induced a limited prolongation of APTT. LMWH might be useful for controlling acute hemolysis in patients with PNH and reducing the dose of adrenocortical hormone.关键词
阵发性睡眠性血红蛋白尿症/溶血/治疗/低分子量肝素/肾上腺糖皮质激素Key words
paroxysmal nocturnal hemoglobinuria/hemolysis/treatment/low-molecular weight heparin/adrenocortical hormone分类
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赵明峰,邵宗鸿,刘鸿,曹铮,田鹏,付蓉,施均,何广胜,白洁,杨天楹..低分子量肝素和肾上腺糖皮质激素对阵发性睡眠性血红蛋白尿症患者红细胞体外溶血抑制作用的研究[J].中华医学杂志（英文版）,2002,115(11):1620-1623,4.
