中国现代医学杂志2005，Vol.15Issue(11)：1620-1623,1631,5.
KiSS-1基因及其蛋白在人胰腺癌组织中表达及其与侵袭和转移的关系
Expression of KiSS-1 in human pancreatic cancer and relationship with their invasion and metastasis
王春晖 1乔宠 2麻树人 3周文平 3戴显伟1
作者信息
- 1. 中国医科大学附属第二医院,普通外科,辽宁,沈阳,110004
- 2. 中国医科大学附属,第二医院,辽宁,沈阳,110004
- 3. 沈阳军区总医院,辽宁,沈阳,110016
- 折叠
摘要
Abstract
[Objective] To investigate the expression of KiSS-1 in human pancreatic cancer in relation to the clinical significance. [Methods] RT-PCR analysis and western blot analysis were used to detect the expression level of KiSS-lmRNA and its protein peptide-metastin in tissues of 37 cases of patients with pancreatic cancer, 27cases of their metastatic site and 9 cases of normal pancreatic tissues. [Results] The expression of KiSS-1 in pancreatic tissues were significantly lower than those in normal (P ＜0.01, P ＜0.01). The expression of KiSS-1 had no correlation with sex, age, size of tumor and histological grade. However, the expression of KiSS-1 was related to the clinical stage, metastasis and nerves invasion significantly. The expression of KiSS-lmRNA and metastin were (0.135±0.121) and (9.23±2.74) μg/100 μg total protein separately in stage Ⅲ and Ⅳ, which were significant lower than those in stage Ⅰ and Ⅱ (P ＜0.05, P ＜0.05). It showed a decreased tendency in pancreatic cancer without metastasis, with metastasis and metastatic site, which was lowest in metastatic site. The expression of KiSS-1 in tumor with nerves invasion were significantly lower than those without nerves invasion (P ＜0.01, P ＜0.01 ), which correlated coefficient (Kendall τ-b) were 0.597(P =0.003) and 0.438 (P =0.007). [Conclusion] The expression of KiSS-1has close relation to invasion and metastasis of human pancreatic cancer, and may be involved in regulation of this process.关键词
KiSS-1/胰腺癌/侵袭/转移Key words
KiSS-1/pancreatic cancer/, invasion/metastasis分类
医药卫生引用本文复制引用
王春晖,乔宠,麻树人,周文平,戴显伟..KiSS-1基因及其蛋白在人胰腺癌组织中表达及其与侵袭和转移的关系[J].中国现代医学杂志,2005,15(11):1620-1623,1631,5.
