中国临床康复2003，Vol.7Issue(11)：1624-1625,2.
糖皮质激素对骨髓基质细胞增殖及分化的影响
The effect of glucocorticoids on marrow stromal cell proliferation and differentiation
摘要
Abstract
Aim To observe the effect of glucocorticoids on marrow stromal cell proliferation and differentiation and study the pathological mechanism of osteoporosis.Methods Bone marrow matrix cells were divided into experiment and control groups according to random number table.Proliferation of marrow stromal cell treated with dexamethasone(1× 10- 7 mol/L) and contents of osteocalcin in the media were measured.Results The number of the marrow stromal cell[(3.73± 0.43)× 105]and the contents of osteocalcin[(5.2± 1.4)ng/mg]in the media of the experimental group obviously decreased compared to the control[(5.76± 0.69)× 105,(12.5± 1.5)ng/mg](t=12.61,7.45,P< 0.001).The number of adipocytes increased with longer duration of exposure to dexamethasone.Conclusion Glucocorticoids inhibited marrow stromal cell proliferation and osteoblastic differentiation, and promoted its differentiation into adipocytes,which is a major contributing factor of bone loss and an increase in marrow fat volume in the osteoporosis.关键词
骨质疏松/糖皮质激素类/骨髓/间质细胞Key words
glucocorticords/osteoporosis/bone marrow/stromal cell分类
医药卫生引用本文复制引用
殷力,李月白,许建中,秦国斌,王义生..糖皮质激素对骨髓基质细胞增殖及分化的影响[J].中国临床康复,2003,7(11):1624-1625,2.基金项目
河南省科委自然科学基金资助项目(984021700) （984021700）
