南京医科大学学报（英文版）2004，Vol.18Issue(3)：163-166,4.
辛伐他丁对原发性高血压左室重量和内皮功能的影响及其改变间关系的研究
Study on the Effect of Simvastatin on Left Ventricular Mass and Endothelial Function and the Relationship between Their Changes in the Patients with Essential Hypertension
摘要
Abstract
Objective: To study the effect of Simvastatin on the left ventricular mass and endothelial function and to investigate the relationship between their changes in the patients with essential hypertension(EH). Methods:50 patients with hypertension without severe complication were divided into two groups in a randomized, controlled and single blind trial. Group I ( n = 25) were given Simvastatin and hydragogue for 12 weeks while Group Ⅱ were given hydragogue during the same time. We detected the left ventricular mass and the brachial artery dilatation induced by reactive hyperemia(DIRH) or nitroglycerin(DING)respectively with ultrasonography in all patients before and after treatment. 25 normal subjects without any treatment were taken as the control. Results: The left ventricular mass index (LVMI)was higher in the two groups of patients[ (133.61 + 31.02)g/m2; (118.04 ± 39.62)g/m2 ]than that in the control (88.79 ± 22.73)g/m2 before treatment( P ＜ 0.01,0.000 1, respectively)while the blood pressure was higher. The DIRH was lower in the two groups of patients(5.93 ± 2.24)%; (6.54 ± 3.16)%than that in the control(13.09 ± 2.99)%, P ＜0.000 1. There was no significantly differences in age, serum concentrations of total cholesterol, trigiyceride, sugar, blood pressure or the DING between two groups of patients and the control(P ＞ 0.05) .And there was no significant difference in the all variables between group I and group Ⅱ before treatment. After treatment the LVMI decreased[ (133.61 ±31.02)g/m2 VS(91.07 ± 16.01)g/m2, P ＜ 0.01]and the DTRH increased[ (5.93 ± 2.24) % VS(13.53 ± 2.38) %, P ＜ 0.01]in the patients of group Ⅰ while there was no significant change in LVMI and DIRH in the patients of group Ⅱ. The blood pressure in the two groups of patients was decreased to the normal. Compared with group Ⅱ, the changes of LVMI and DIRH was higher in patients of group I though the serum concentrations of total cholesterol, triglyceride or sugar were not significantly different. No significant change in serum concentrations oftotal cholesterol, triglyceride or sugar was found during treatment in the two groups of patients. Analysis showed that the LVMI correlated with DIRH and the change of L VMI correlated better with the chauge of DIRH( r = -0.56;0.69, P ＜ 0.000 1, respectly). Conclusions: The increase of left ventricular mass was related with endothelial dysfunction in essential hypertension. Being independent of the changes of serum concentrations of total cholesterol, triglyceride or sugar and blood pressure, Simvastatin could inhibit the increase of left ventricular mass and improve endothelial function.关键词
原发性高血压/辛伐他丁/左室重量/内皮功能Key words
essential hypenension/simvastatin/left ventricular mass/endothelial function分类
医药卫生引用本文复制引用
张平洋,邓又斌,杨好意,毕小军,潘敏..辛伐他丁对原发性高血压左室重量和内皮功能的影响及其改变间关系的研究[J].南京医科大学学报（英文版）,2004,18(3):163-166,4.基金项目
Supported in part by a grant from the Chinese Ministry of science and technology(30270560) （30270560）
