中德临床肿瘤学杂志（英文版）2005，Vol.4Issue(3)：164-166,3.
Survivin基因在骨肉瘤中的表达及其与临床耐药的相关性研究
Expression of Survivin Gene and Its Relationship with Clinical Multidrug Resistance in Osteosarcoma
摘要
Abstract
To study the expression of survivin and its relationship with clinical multidrug resistance in osteosarcoma. Methods: By using immunohistochemistry (S-P) method, the expression of Survivin in osteosarcoma, osteochondroma and normal osseous tissue, and the expression of P-glycoprotein in osteosarcoma was detected. Results: Survivin positive expression rate was 65.71% in osteosarcoma, but no expression of Survivin was detectable in osteochondroma and normal osseous tissue. The positive expression rate of Survivin was significantly associated with Enneking clinical stages and histological typing (WHO), but no relationship was found among Survivin expression and age, sex and tumor location. The positive expression rate of P-glycoprotein was 45.71%. There was a significant correlation between Survivin and p-glycoprotein. Conclusion: Survivin overexpression was significantly associated with clinical multidrug resistance in osteosarcoma. It could be a potential target for treatment of osteosarcoma.关键词
骨肉瘤/Survivin基因/免疫组织化学Key words
osteosarcoma/Survivin/immunohistochemistry分类
医药卫生引用本文复制引用
聂涛,戴闽,宗世璋..Survivin基因在骨肉瘤中的表达及其与临床耐药的相关性研究[J].中德临床肿瘤学杂志（英文版）,2005,4(3):164-166,3.基金项目
The project was supported by the reasearch of Education Institution in Jiangxi (No. E040506). （No. E040506）
