中华医学杂志（英文版）2007，Vol.120Issue(19)：1655-1658,4.
Prognostic factors and staging systems of multiple myeloma:a single centre study in China
Prognostic factors and staging systems of multiple myeloma:a single centre study in China
TAO Zhong-fei 1FU Wei-jun 1YUAN Zhen-gang 1WANG Dong-xing 1CHEN Yu-bao 1HOU Jian1
作者信息
- 1. Department of Haematology, Shanghai Changzheng Hospital,Second Military Medical University, Shanghai 200003, China
- 折叠
摘要
Abstract
Background Previous studies found a range of prognostic factors but no consensus about the proper staging system for multiple myeloma has been achieved. This study explored the prognostic factors to find a staging system for multiple myeloma most suitable for Chinese patients.Methods Between February 1990 to August 2004, 206 patients (138 men and 68 women, mean aged (59±11) years)who were initially diagnosed as multiple myeloma in Changzheng Hospital (Shanghai, China) and had followup records were enrolled in this study. Potential prognostic factors were evaluated by univariate and multivariate analyses. Four staging systems were applied to compare their suitability for the patients.Results The median survival time of the patients was 33 months. The 1-, 3- and 5-year survival rates were 80.18%,48.08% and 33.7% respectively. Factors identified as adversely affecting survival were older age, severe bone lesions,low haemoglobin, low platelet, low serum calcium, low serum albumin, high proportion of plasma cells in marrow, high serum creatinine, high serum β2 microglobulin and high C-reactive protein. Among these, only C-reactive protein, β2 microglobulin, albumin and age were the independent prognostic factors. There were statistically significant survival differences among the three groups in Durie Salmon staging system and Bataille staging system, but not in British Medical Research Council staging system or International Staging System.Conclusions High β2 microglobulin, high C-reactive protein, low albumin and old age are independent prognostic factors of multiple myeloma. Bataille staging system appears to be optimal for Chinese multiple myeloma patients.关键词
multiple myeloma/ prognosis/ survival analysis/ clinical staging systemKey words
multiple myeloma/ prognosis/ survival analysis/ clinical staging system分类
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TAO Zhong-fei,FU Wei-jun,YUAN Zhen-gang,WANG Dong-xing,CHEN Yu-bao ,HOU Jian..Prognostic factors and staging systems of multiple myeloma:a single centre study in China[J].中华医学杂志（英文版）,2007,120(19):1655-1658,4.
