中国现代医学杂志2006，Vol.16Issue(2)：166-170,5.
肾上腺髓质素对大鼠局灶性脑缺血再灌注后脑组织的保护作用
Protection of adrenomedullin after focal cerebral ischemia/reperfusion in rats
毕国荣 1张辉 1周慧杰 1方秀斌2
作者信息
- 1. 中国医科大学第二临床学院,神经内科,辽宁,沈阳,110004
- 2. 中国医科大学基础医学院,神经生物学教研室,辽宁,沈阳,110004
- 折叠
摘要
Abstract
[Objective] To investigate the effect of Adrenomedullin (ADM) after middle cerebral artery occlusion (MCAO) in rats. [Method] Using the model of middle cerebral artery occlusion (MCAO) in rats, 2 hours ischemia followed by various time of reperfusion, expression of ADM at the each time point by immunohistochemistry, continuously. [Results] ADM expressed in normal rats, and increased a little in sham group, without significant difference compared to the control group (P ＞0.05); after cerebral ischemia/reperfusion, ADM positive cells increased in ischemia cortex, with significant different compared to the normal control group and the sham group (P＜0.05), ABM positive cells increased in ischemia sector and contralateral after cerebral ischemia repeffusion, but it was more evidence in ischemia area (P ＜0.05). Observing continuously, the number of ADM positive cells increased after reperfusion of 4 hours post-MCAO, reaching climax after 6 hours post-MCAO, and remained elevated for up to 7 days.[ Conclusions ] The expression of ADM increased for its cerebrovascular function after cerebral ischemia/reperfusion.关键词
脑缺血再灌注/肾上腺髓质素/免疫组织化学染色法Key words
cerebral ischemia/reperfusion/Adrenomedullin/immunohistochemical method分类
医药卫生引用本文复制引用
毕国荣,张辉,周慧杰,方秀斌..肾上腺髓质素对大鼠局灶性脑缺血再灌注后脑组织的保护作用[J].中国现代医学杂志,2006,16(2):166-170,5.
