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Ghrelin receptor gene polymorphisms are associated with female metabolic syndrome in Chinese population

LI Wei-ju ZHEN Yi-song SUN Kai XUE Hao SONG Xiao-dong WANG Yi-bo FAN Xiao-han HAN Yun-feng HUI Ru-tai

中华医学杂志（英文版）2008，Vol.121Issue(17)：1666-1669,4.
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中华医学杂志（英文版）2008，Vol.121Issue(17)：1666-1669,4.

Ghrelin receptor gene polymorphisms are associated with female metabolic syndrome in Chinese population

Ghrelin receptor gene polymorphisms are associated with female metabolic syndrome in Chinese population

LI Wei-ju 1ZHEN Yi-song 2SUN Kai 3XUE Hao 2SONG Xiao-dong 4WANG Yi-bo 1FAN Xiao-han 2HAN Yun-feng 4HUI Ru-tai2

作者信息

  • 1. Hypertension Division,Fuwai Hospital and Cardiovascular Institute,Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037,China
  • 2. Hypertension Division,Fuwai Hospital and Cardiovascular Institute
  • 3. Key Laboratory of Clinical Cardiovascular Genetics Ministry of Education,,Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037,China
  • 4. Key Laboratory of Clinical Cardiovascular Genetics Ministry of Education,Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037,China
  • 折叠

摘要

Abstract

Background The ghrelin plays an important role in the regulation of food intake and energy homeostasis.Therefore,the ghrelin receptor gene (GHSR) is an excellent candidate for studying metabolic syndrome.This study aimed to investigate whether polymorphisms in ghrelin receptor gene are associated with metabolic syndrome in Chinese population.Methods Subjects consisted of 698 patients aged 41 to 80 years,diagnosed as metabolic syndrome by International Diabetes Federation (IDF) 2005 criteria,and 762 age-and gender-matched controls.Three variants within the GHSR were selected and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).Odds ratios were estimated using a case-control study design by controlling confounding factors.Results The NA genotype (rs2922126) in the promoter was associated with metabolic syndrome (OR 1.41,95%CI 1.03-1.94),increased waist circumference (OR 1.75,95%CI 1.26-2.42),and increased fast blood glucose (OR 1.49,95%CI 1.07-2.06) in women.The A/A genotype (rs509030) in the intron was associated with lower plasma high density lipoprotein in women (OR 1.37,95%CI 1.02-1.84).Conclusion The polymorphisms within GHSR might be a genetic risk factor for metabolic syndrome in women.

关键词

metabolic syndrome/polymorphism/ghrelin receptor

Key words

metabolic syndrome/polymorphism/ghrelin receptor

分类

医药卫生

引用本文复制引用

LI Wei-ju,ZHEN Yi-song,SUN Kai,XUE Hao,SONG Xiao-dong,WANG Yi-bo,FAN Xiao-han,HAN Yun-feng,HUI Ru-tai..Ghrelin receptor gene polymorphisms are associated with female metabolic syndrome in Chinese population[J].中华医学杂志（英文版）,2008,121(17):1666-1669,4.

基金项目

The study was supported by a grant from Ministry of Science & Technology of China (No.2006CB503805). （No.2006CB503805）

中华医学杂志（英文版）

OACSTPCDMEDLINESCI

0366-6999

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