南京医科大学学报（英文版）2005，Vol.19Issue(4)：167-172,6.
Serotonin in human skin
Serotonin in human skin
Jianguo Huang 1Qiying Gong 2Guiming Li2
作者信息
- 1. Department Of Dermatology, Bispebjerg Hospital, Bispebjerg Bakke 23,2400 Copenhagen, Denmark
- 2. Department of Dermatology, the First Affiliated Hospital of Chongqing University of Medical Science, Chongqing, 410006, China
- 折叠
摘要
Abstract
In this review the authors summarize data of a potential role for serotonin in human skin physiology and pathology. The uncovering of endogenous serotonin synthesis and its transformation to melatonin underlines a putative important role of this pathway in melanocyte physiology and pathology. Pathways of the biosynthesis and biodegradation of serotonin have been characterized in human beings and its major cellular populations. Moreover, receptors of serotonin are expressed on keratinocytes, melanocytes, and fibroblasts and these mediate phenotypic actions on cellular proliferation and differentiation. And the widespread expression of a cutaneous seorotoninergic system indicates considerable selectivity of action to facilitate intra-, auto-, or paracrine mechanisms that define and influence skin function in a highly compartmentalized manner. Melatonin, in turn, can also act as a hormone, neurotransmitter, cytokine, biological modifier and immunomodulator. Thus, Serotonin local synthesis and cellular localization could thus become of great importance in the diagnosis and management of cutaneous pathology.关键词
serotonin/human skinKey words
serotonin/human skin分类
医药卫生引用本文复制引用
Jianguo Huang,Qiying Gong,Guiming Li..Serotonin in human skin[J].南京医科大学学报（英文版）,2005,19(4):167-172,6.
