中国药理学与毒理学杂志2007，Vol.21Issue(3)：167-173,7.
苦参碱对豚鼠心肌细胞钾电流的抑制作用
Inhibition of matrine on potassium currents in guinea pig ventricular myocytes
摘要
Abstract
AIM To elucidate the possible antiarrhythmic mechanism of matrine. METHODS Whole-cell patch-clamp technique was used to record ionic currents in ventricular myocytes. RESULTS In guinea pig ventricular myocytes, matrine 100 μmol·L-1 prolonged 90% action potential duration (APD90) by 40% at a stimulation of 0.1 Hz in a frequency-independent manner, inhibited IK1 by 47% at the test potential of -120 mV, reduced IKr,tail by 50% and had no effect on IKs,tail. CONCLUSION Matrine prolonged APD through blockade of multiple potassium currents, which may relate to its antiarrhythmic efficacy.关键词
苦参碱/心肌/钾通道/膜片钳技术,全细胞Key words
matrine/myocardium/potassium channels/patch clamp techniques, whole-cell分类
医药卫生引用本文复制引用
周宇宏,许超千,单宏丽,吕延杰,杨宝峰..苦参碱对豚鼠心肌细胞钾电流的抑制作用[J].中国药理学与毒理学杂志,2007,21(3):167-173,7.基金项目
国家自然科学基金重点项目(30430780) （30430780）
国家自然科学基金项目(30572181) （30572181）
