Inhibitive effect of 3-bromopyruvic acid on human breast cancer MCF-7 cells involves cell cycle arrest and apoptotic inductionOACSTPCD
Inhibitive effect of 3-bromopyruvic acid on human breast cancer MCF-7 cells involves cell cycle arrest and apoptotic induction
Background Breast cancer is one of the most common malignancies in women and is highly resistant to chemotherapy. Due to its high tumour selectivity, 3-bromopyruvic acid (3-BrPA), a well-known inhibitor of energy metabolism h…查看全部>>
Background Breast cancer is one of the most common malignancies in women and is highly resistant to chemotherapy. Due to its high tumour selectivity, 3-bromopyruvic acid (3-BrPA), a well-known inhibitor of energy metabolism has been proposed as a specific anticancer agent. The present study determined the effect of 3-BrPA on proliferation, cell cycle and apoptosis in the human breast cancer MCF-7 cell line and other antitumour mechanisms. Methods MCF-7 cells…查看全部>>
LIU Xiao-hong;ZHENG Xue-fang;WANG Yong-li
Department of Pharmacology,Hebei Medical University,Shijiazhuang,Hebei 050017,ChinaDepartment of Pharmacy,Tangshan Gongren Hospital,Tangshan,Hebei 063000,ChinaLiaoning Key Lab of Bioorganic Chemistry,Dalian University,Dalian,Liaoning 116622,China
医药卫生
apoptosiscell cyclebreast cancer3-bromopyruvic acid
apoptosiscell cyclebreast cancer3-bromopyruvic acid
《中华医学杂志（英文版）》 2009 (14)
光诱导肌红蛋白的去氧、结合氧及传能机制研究
1681-1685,5
This work was supported by the Natural Science Foundation of China (No. 20871024), Program for Liaoning Excellent Talents in University (No. RC-04-10), and Liaoning Innovative Research Team in University (No. 2006T002, 2009T003).
评论