南京医科大学学报（英文版）2008，Vol.22Issue(3)：168-171,4.
Relationship among plasma endothelin, calcitonin gene-related peptide and blood flow rate of bilateral vertebral arteries in patients with cervical vertigo
Relationship among plasma endothelin, calcitonin gene-related peptide and blood flow rate of bilateral vertebral arteries in patients with cervical vertigo
Jiajun Wei 1Jinzhi Xu 1Suming Zhang1
作者信息
- 1. Department of Neurology, the Tongji Hospital Affiliated to Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
- 折叠
摘要
Abstract
Objective: To investigate the relationship among plasma endothelin(ET), calcitonin gene-related peptide(CGRP) and blood flow rate of bilateral vertebral arteries in patients with cervical vertigo(CV) and to assess the effect of ET and CGRP on the onset of CV.Methods:The concentration of ET and CGRP in 64 patients with CV and 30 controls was determined by radioimmunity method. The average blood flow velocity (Vm) of bilateral vertebral arteries was detected by Transcranial Doppler(TCD). Results:Plasma concentration of ET(91.48±9.08 pg/ml) and ET/CGRP ratio value(2.88±0.52) in vertebrobasilar arteriospasm group were both higher than those in vertebrobasilar non-arteriospasm group and in controls, while CGRP concentration(30.66±6.05 pg/ml) in vertebrobasilar arteriospasm group was lower than that in vertebrobasilar non-arteriospasm group and controls respectively. The Vm of bilateral vertebral arteries in vertebrobasilar arteriospasm group(67,97±11.64 cm/s) was higher than that in vertebrobasilar non-arteriospasm group and controls respectively, having a positive correlation with ET concentration and ET/CGRP ratio value(r1=0.52, P＜0.05; r2=0.59,P＜0.05), but a negative correlation with CGRP concentration(r3=-0.54, P＜0.05). There was no significant difference in ET and CGRP concentration, ET/CGRP ratio value and the Vm of bilateral vertebral arteries between vertebrobasilar non-arteriospasm group and the control group. Conclusion: All the results indicate that ET and CGRP are possibly the most important substance factors at the onset of CV with vertebrobasilar arteriospasm, and their imbalance of regulating vertebrobasilar arterial contraction and relaxation may play an important role in the onset of CV with vertebrobasilar arteriospasm.关键词
cervical vertigo/ endothelin/ calcitonin gene-related peptideKey words
cervical vertigo/ endothelin/ calcitonin gene-related peptide分类
基础医学引用本文复制引用
Jiajun Wei,Jinzhi Xu,Suming Zhang..Relationship among plasma endothelin, calcitonin gene-related peptide and blood flow rate of bilateral vertebral arteries in patients with cervical vertigo[J].南京医科大学学报（英文版）,2008,22(3):168-171,4.
