中国临床康复2002，Vol.6Issue(11)：1698-1699,2.
尼莫地平对脑梗死患者康复期认知功能干预的临床和实验研究
The clinical and experimental study of the efficacy of nimodiping in cognitive rehabilitation of cerebral infarction
徐晓云 1黄蕾 1王德生 2温淑荣2
作者信息
- 1. Shanghai East Hospital,Shanghai 200120,China
- 2. First Affiliated Hospital,Haerbin Medical Universtiy,Haerbin 150001,China
- 折叠
摘要
Abstract
Objective To study the efficacy of nimodipine in cognitive rehabilitation of the cerebral infarction.Method (1)Experimental animal models were created in 24 month old Wistar rats,which were treated with nimodipine.Results were compared among the drug treated group,non treated of the same age mice group and 8 month old mice group.(2)Clinical research of nimodipine was conducted in 67 cerebral infarction patients with cognitive impairments.HDS was used as measuring tool.(3)To analyze the related factors such as age,Barthel index and FAQ.Result After 1 month treatment of nimodipine,significant differences between drug dealing and non drug dealing groups were showed in the Y maze discrimination learning experiment(P< 0.05),the duration and errors were improved in drug treated group compared with control group.No significant different result was found in one trial passive avoidance response experiment(P >0.05);single factor analysis(including Barthel index,FAQ and age) did not show significance(P >0.05);there is no statistical differences between nimodipine treated patients and non drug treatment patients(P >0.05).Conclusion Nimodipine showed no efficacy to cognitive rehabilitation in cerebral infarctions. 关键词
cerebral infarction/cognitive/nimodipine/clinical animal experimentKey words
cerebral infarction/cognitive/nimodipine/clinical animal experiment分类
医药卫生引用本文复制引用
徐晓云,黄蕾,王德生,温淑荣..尼莫地平对脑梗死患者康复期认知功能干预的临床和实验研究[J].中国临床康复,2002,6(11):1698-1699,2.
