中国药科大学学报2001，Vol.32Issue(1)：1-7,7.
二硫戊环异硫脲类化合物的合成及其一氧化氮合酶抑制活性研究
Studies on Synthesis and iNOS Inhibitory Activity of Dithiolane Isothiourea Compounds
摘要
Abstract
Objective: To search for novel potent compounds with PAF receptorantagonistic and iNOS inhibitory activities for the treatment of septic shock. Method: Isothiourea functional groups were introduced into the structure of PAF receptor antagonists, the iNOS inhibitory activity of the target compounds were measured according to kit method. Results and Conclusion: Twenty four dithiolane isothiourea compounds (ZW1-24) were synthesized, and their structures were confirmed by IR, 1HNMR, MS spectra and elementary analysis. The results of preliminary pharmacological test showed that ZW-6,ZW -9, ZW-19, ZW-23 and ZW-24 had comparable activity to the control aminoguanidine, while -21 was more potent than aminoguanidine.关键词
PAF受体拮抗剂/iNOS抑制剂/败血性休克/二硫戊环类化合物/异硫脲分类
医药卫生引用本文复制引用
王德传,张奕华,彭司勋,朱东亚,姚红红,尤启冬..二硫戊环异硫脲类化合物的合成及其一氧化氮合酶抑制活性研究[J].中国药科大学学报,2001,32(1):1-7,7.基金项目
国家自然科学基金资助项目 （）
