中华医学杂志（英文版）2001，Vol.114Issue(2)：170-172,3.
视黄酸调节胰岛素样生长因子基因在脐血淋巴细胞的表达
Retinoic acid regulated insulin-like growth factor gene expression in cord blood lymphocytes
杨毅 1王卫平 1苏贻新1
作者信息
- 1. 复旦大学医学院儿科医院 上海 200032
- 折叠
摘要
Abstract
Objective To explore the immune promotion mechanism of retinoic acid (RA).
Methods Reverse Transcription-Polymerase chain reaction (RT-PCR) was used to detect the gene expression of insulin like growth factor Ⅰ (IGF-Ⅰ) and IGF receptors (IGF-IR and IGF-IIR) in vitro, and their regulation by RA in human cord blood lymphocyte (CBL).
Results Significant upregulation of IGF-I, IGF-IR and IGF-IIR mRNA was found at 6-24 hours in CBL incubated with physiologic concentrations of RA as compared to those without RA.
Conclusion The enhancement of IGF expression may be an important pathway for vitamin A to promote immune cellular functions.关键词
视黄酸/脐血淋巴细胞/胰岛素样生长因子/基因Key words
retinoic acid/insulin like growth factor/cord blood lymphocyte分类
医药卫生引用本文复制引用
杨毅,王卫平,苏贻新..视黄酸调节胰岛素样生长因子基因在脐血淋巴细胞的表达[J].中华医学杂志（英文版）,2001,114(2):170-172,3.
