临床医学工程2009，Vol.16Issue(7)：17-18,2.
伊曲康唑醇质体的制备及体外经皮渗透研究
Study on the Preparation and Transdermal Penetration of ltraconazole Ethosome Gel
吴培诚 1吴园园 2卢安根3
作者信息
- 1. 广东药学院基础学院,广东,广州,510006
- 2. 深圳赛保尔生物药业有限公司,广东,深圳,518129
- 3. 广西分析测试研究中心,广西,南宁,530022
- 折叠
摘要
Abstract
Objective To investigate the feasibility of ethosmoe gel as transdemal carries of ltraconazole. Methods Itraconazole was encapsulated in ethosomes composed of phospholipids and ethanol, then ethosomes were incorporated in earbopol gel. Percutaneous perme-ation of Itraconazole was observed using rat skin and Franz transdermal diffusion device in vitro. The concentration of Itraconazole in receptor compartment at specified time points were determined by HPLC. The steady flux and the accumulation quantity of Itraconazole in epidermis and dermis were calculated. Results The flux of Itraconazole from ethosome gel were 9.20, and 1.97 times higher than that from aqueous solu-tion, 30% ethanol HP-β-CD solution gel preparation, respectively. Conclusion Ethosome gel is effective for transdemal delivery and increased the Itraconazole amount retained in the skin.关键词
伊曲康唑/凝胶/醇质体/透皮给药Key words
Itraconazole/gel/ethosome/transdermal drug delivery分类
医药卫生引用本文复制引用
吴培诚,吴园园,卢安根..伊曲康唑醇质体的制备及体外经皮渗透研究[J].临床医学工程,2009,16(7):17-18,2.
