第一军医大学学报2001，Vol.21Issue(1)：17-18,2.
甲状腺肿瘤增殖细胞核抗原表达的免疫组化研究
Immunohistochemical study of proliferating cell nuclear antigen on thyroid tumors
摘要
Abstract
Objective To evaluate the significance and practical value ofexamining the expression of proliferating cell nuclear antigen(PCNA) in the differentiation and diagnosis of thyroid tumors. Methods The expression of PCNA in the tumor tissues in 14 cases of thyroid adenoma,10 cases of atypical adenoma,15 papillary carcinoma,10 follicular carcinoma,10 medullary thyroid carcinoma and 10 undifferentiated carcinoma were determined by immunohistochemical method with strept avidin-biotin (LSAB). Results PCNA proliferating index were 12.8 in thyroid adenoma,19.8 in atypical adenoma,19.2 in papillary carcinoma, 26.4 follicular carcinoma, 27.9 in medullary thyroid carcinoma and 44.3 in undifferentiated carcinoma. No significant difference in the PCNA proliferating index between thyroid adenoma and papillary carcinoma was observed,while that between thyroid adenoma and atypical adenoid tumors along with various carcinomas was found to be significantly different (P<0.01). Conclusions PCNA proliferating index may be useful indicators for the differentiation and diagnosis of thyroid tumors and for the prognostic assessment.关键词
甲状腺肿瘤/增殖细胞核抗原/免疫组织化学分类
医药卫生引用本文复制引用
孙青,鹿伟,张传森,吴彩志,高钟禹,孙德刚..甲状腺肿瘤增殖细胞核抗原表达的免疫组化研究[J].第一军医大学学报,2001,21(1):17-18,2.基金项目
山东省卫生厅医药卫生科研基金资助项目( （）
