中国现代医学杂志2004，Vol.14Issue(22)：17-20,4.
钾离子通道的活性状态对蛛网膜下腔注射腺苷抗伤害性作用的影响
Effect of adenosine triphosphate-sensitive potassium channel on antinociception of intrathecal adenosine agonist in rats
麻海春 1王艳芬 2曾维安 3冯春生 4韩树海 1卢宝顺 1赵华1
作者信息
- 1. 吉林大学第一医院麻醉科,吉林,长春,130021
- 2. 吉林大学基础医学院生理教研室,吉林,长春,130021
- 3. 吉林大学第二医院消化科,吉林,长春,130041
- 4. 中山大学肿瘤防治中心麻醉科,广东,广州,510120
- 折叠
摘要
Abstract
Objective: To investigate the effect of adenosine triphosphate-sensitive potassium channel (K+ATP) on the antinociception of adenosine agonist R-phenylisopropyladenosine (R-PIA) administered into intrathecal (IT) on conscious rats. Methods: Sprague-Dawley rat was inserted intrathecal catheter (PE-10, 8.5 cm) to the lumbar subarachnoid space under pentobarbital anesthesia. After one week of recovery from surgery, antinociceptive effect was tested by tail-flick latency method after R-PIA injection into IT with K+ATP opener nicorandil or inhibitor glibenclamide. Results: Microinjection of R-PIA into IT produced a significant does- and time-dependent antinociceptive action (P ＜0.05). The intrathecal administration of 5μg nicorandil and 2μg glibenclamide alone did not produce any antinociceptive effect (P ＞0.05), but nicorandil did strengthen the antinociception induced by intrathecal R-PIA,glibenclamide did weaken the antinociception induced by intrathecal R-PIA respectively (P ＜0.05). Conclusions:The present results suggest that adenosine agonist R-PIA administered into IT produce the antinociceptive effect on painful stimulation via K+ATP channel activation at the spinal cord level.关键词
鞘内/腺苷/抗伤害作用/钾离子通道Key words
intrathecal/adenosine/analgesic/K+ channel分类
医药卫生引用本文复制引用
麻海春,王艳芬,曾维安,冯春生,韩树海,卢宝顺,赵华..钾离子通道的活性状态对蛛网膜下腔注射腺苷抗伤害性作用的影响[J].中国现代医学杂志,2004,14(22):17-20,4.
