中国动脉硬化杂志2001，Vol.9Issue(1)：17-20,4.
刺梨汁对金黄地鼠的抗动脉粥样硬化作用
Effect of Rose Roxburghii Tratt Juice on Atherosclerosis in Hypercholesterolemic Hamsters
摘要
Abstract
Aim To look for effective antioxidant to reduce risk ofatherosclerosis. Methods The golden harmsters were fed for 10 weeks on a hypercholesterolemic diet. The animals received either vitamin C, vitamin E or juice of rose roxburghii tratt (JRRT) supplement in their diet except control animals. Results The level of corresponding antioxidants in various antioxidant-supplemented animals were increased compared to controls. The antioxidants induced the prolongation of lag time in low density lipoprotein (LDL) oxidation in vitamin C, vitamin E, JRRT groups compared with controls (221±56 min, 222±60 min, 248±48 min, and 181±47 min, compared between groups, P<0.05, respectively) and decreased the area of atherosclerosis lesion (2.63%±1.35%, 2.44%±1.47%, 1.43%±0.92%, and 5.62%±1.28%, compared between groups, P<0.001, respectively). Regression analysis showed that there was a negative relationship between the area of atherosclerosis lesion and LDL susceptibility. LDL susceptibilty was also correlated with the plasma level of vitamin E. Conclusions Antioxidants decrease extent of atherosclerosis lesion, and this may be caused by change in susceptibility of LDL oxidation. JRRT is a strong antioxidant for reducing risk of atherosclerosis.关键词
动脉粥样硬化/脂蛋白,低密度/抗氧化剂/利梨汁/维生素C/金黄地鼠分类
医药卫生引用本文复制引用
汪俊军,刘小传,刘效林,庄一义,李露言..刺梨汁对金黄地鼠的抗动脉粥样硬化作用[J].中国动脉硬化杂志,2001,9(1):17-20,4.基金项目
江苏省应用基础研究基金(BJ97111)资助 （BJ97111）
