中国现代医学杂志2004，Vol.14Issue(2)：17-20,4.
卵巢上皮性肿瘤患者血清血管内皮生长因子的诊断及预后意义
Diagnostic and prognostic significance serum VEGF level in epithelial ovarian neoplasms
李海玲 1任慕兰 1赵维英1
作者信息
- 1. 东南大学附属中大医院,妇产科,江苏,南京,210009
- 折叠
摘要
Abstract
Objective: To determine whether serun vascular endothelial growth factor could be used as a diagnostic and prognostic marker in ovarian cancer patients. Methods: Vascular endothelial growth factor in pretreatment serum samples of 61 patients with epithelial ovarian neoplasms (47 malignant and 14 benign)and 11 normal women in control group was measured by enzymelinked immunosorbent assay. Results: The mean preoperative serum VEGF levels in epithelial ovarian carcinoma, in benign disease and in control were 221.81 pg/ml (95% confidence interval (CI) 180.35 ～262.87 pg/ml), 158.21 pg/ml (95% CI 27.32 ～279.10 pg/ml) and 121. 48 pg/ml (95% CI 34.13 ～228.32 pg/ml) respectively . But their difference had no statistical significance (P ＞ 0.05 ). Preoperative serum VEGF level in 38 advanced ovarian carcinomas was higher than that in 9 early ovarian carcinomas ( P ＜ 0.05 )Serum VEGF level was high in those with poor histological differentiation(G3 ) (P ＜ 0.05). Serum VEGF level did not have correlation with histological types ( P ＞ 0.05 ). 29 cases had completely cytorednctive surgery. With their post - operation data, elevated preoperative VEGF serum level was correlated with a poorer outcome in two years (P ＜ 0.05 ) . Conclusions: Vascular endothelial growth factor appears to be an additional factor for predicting prognosis of patients with epithelial ovarian cancer.关键词
血管内皮生长因子(VEGF)/卵巢上皮性肿瘤/血管生成Key words
vascular edothelial gowth fctor(VEGF)/eithelial ovarian tumor/agiogenesis分类
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李海玲,任慕兰,赵维英..卵巢上皮性肿瘤患者血清血管内皮生长因子的诊断及预后意义[J].中国现代医学杂志,2004,14(2):17-20,4.
