河南医科大学学报2001，Vol.36Issue(2)：172-174,3.
人脑星形细胞肿瘤中细胞凋亡及bcl-2，Bax基因的表达
Study on apoptosis and the expression of bcl-2 and Bax in tissues with human cerebral astrocytic tumor
谭占国 1卢权 2柴宗举 3朱贤立4
作者信息
- 1. 河南医科大学博士后流动站
- 2. 平顶山平煤集团高庄矿中心医院神经外科
- 3. 禹州市第二人民医院神经外科
- 4. 同济医科大学附属协和医院神经外科
- 折叠
摘要
Abstract
Aim: To investigate the status of apoptosis and the relationship between apoptosis and the expression of its related-genes bcl-2 and Bax in tissues with astrocytic tumor. Methods: TUNEL and immunohistochemical S-P technique were used to determine apoptotic cell density (AD), bcl-2 and Bax expression in thirty cases of cerebral astrocytic tumor. Results: Apoptosis was very common in all the thirty cases.AD in astrocytoma tissues presented a significant decreasing trends with the tumor grade of maligance increasing. Meanwhile, it was found that bcl-2 and Bax positive expression in astrocytic tumor were 50% and 100% respectively. The extent of bcl-2 expression had a significant negative corrlation with AD (r=-0.922, P<0.001). No relationship was found between Bax expression and AD (P＞0.05). Conclusion: The inhibition of cell apoptosis may play an important role in astrocytic tumorigenesis and its anaplastia. The product of bcl-2 gene expression may inhibit cell apoptosis in tissues of astrocytic tumor. Bax gene may regulate tumor cell apoptosis via more complicated mechnism, which remains to be elucidated by further research.关键词
星形细胞肿瘤/细胞凋亡/相关基因分类
医药卫生引用本文复制引用
谭占国,卢权,柴宗举,朱贤立..人脑星形细胞肿瘤中细胞凋亡及bcl-2，Bax基因的表达[J].河南医科大学学报,2001,36(2):172-174,3.
