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Immunomodulation effects of heat-treated Enterococcus faecalis FK-23(FK-23) in mice

Takashi Shimada Yunqing Cai Lei Cheng Chie Motonaga Kazutake Fukada Yoshihisa Kitamura Jieshu Wu

南京医科大学学报(英文版)2009，Vol.23Issue(3)：173-176,4.

Immunomodulation effects of heat-treated Enterococcus faecalis FK-23(FK-23) in mice

Takashi Shimada ¹Yunqing Cai ¹Lei Cheng ¹Chie Motonaga ²Kazutake Fukada ²Yoshihisa Kitamura ¹Jieshu Wu¹

作者信息

1. China-Japan Collaborating Centre for Probiotics Research, Nanjing Medical University, Nanjing, 210029, China
2. Central Research Laboratories, Nichinichi Pharmaceutical Co., Ltd., Mie518-1417, Japan
折叠

摘要

Abstract

Objective:The purpose of this study was to evaluate the effects of Enterococcus faecalis FK-23(FK-23) on the immune function in mice. Methods:Mice were treated with three doses of the FK-23(0.05, 0.1, 0.2, 0.6 g/kg body weight) for 30 days. Delayed type hypersensitivity (DTH), monocyte phagocytic function, serum hemolysis antibody and natural killer cell activity were studied. Results: The significant increases in mice treated with 0.6 g/kg bw were found in DTH, phagocytic function of monocyte, serum hemolysis antibody and natural killer cell activity. Conclusion:The results from the present study suggest that FK-23 could improve both specific and nonspecific immune function.

关键词

FK-23/ immunologic function/ probiotics

Key words

FK-23/ immunologic function/ probiotics

分类

医药卫生

引用本文复制引用

Takashi Shimada,Yunqing Cai,Lei Cheng,Chie Motonaga,Kazutake Fukada,Yoshihisa Kitamura,Jieshu Wu..Immunomodulation effects of heat-treated Enterococcus faecalis FK-23(FK-23) in mice[J].南京医科大学学报(英文版),2009,23(3):173-176,4.

基金项目

Ths work was supported by Sino-Japanese Cooperation Projects (1738). （1738）

南京医科大学学报(英文版)

ISSN：1674-8301

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