中德临床肿瘤学杂志（英文版）2005，Vol.4Issue(3)：174-178,5.
注射用重组改构人肿瘤坏死因子联合化疗治疗晚期恶性肿瘤的临床观察
Recombination Mutant Human Tumor Necrosis Factor Combined with Chemotherapy in the Treatment of Advanced Cancer
刘星 1张祥福 1郑知文 1卢辉山 1吴心愿 1黄昌明 1王川 1官国先1
作者信息
- 1. 福建医科大学附属协和医院肿瘤科,350001
- 折叠
摘要
Abstract
Past studies showed that tumor necrosis factor (TNF) assisted anti-tumor treatment and intensified the sensitivity of chemotherapy. However its clinical application has been curbed because of its low purity, high dosage, and strong toxicity. The objective of present study is to evaluate the therapeutic effects and adverse reactions of recombinant mutant human tumor necrosis factor (rmhTNF) combined with chemotherapy in patients with advanced malignant tumor. Methods: 105 patients with advanced malignant tumor were randomly divided into trial group, 69 patients, and control group, 36 patients.rmhTNF was injected intramuscularly to the trial group at a dose of 4×106 U/m2, from the 1st to 7th days, the 11th to 17th days combined with chemotherapy course. The chemotherapy plan was as follows:CAP for patients with the NSCLC; FAM for patients with gastric cancer; FC for patients with colorectal cancer. One treatment cycle lasted for 21 days and two cycles were scheduled. The control group was given only the same chemotherapy as the trial group. Results: In the trial group there was 1 CR case and 12 PR cases, and the response rate was 13/69 (18.84%); in the control group 1 PR case, the response rate 1/36 (2.78%). The response rate in the trial group was significantly higher than that in the control group (P=0.022). The response rate for NSCLC in the trial group was 8/17 (47.06%), and 1/6 (16.67%) in the control group. The response rates for gastric cancer and colorectal cancer in the trial groups also were higher than those in the control groups. After the treatment the KPS was 89.00±9.92 in the trial group,and 84.17±8.84 in the control group, with a significant difference between the two groups (P=0.028). The adverse reactions of rmhTNF injection included: pain in the injection area, chill, hardening and swelling and redness in the injection area, fever, ostealgia and myosalgia, and cold-like symptoms. All these adverse reactions were mild and bearable. Conclusion: The administration of rmhTNF in combination with general chemotherapy is an effective and secure means in treating advanced malignant tumor.关键词
肿瘤坏死因子/生物疗法/化学疗法/综合疗法Key words
tumor necrosis factor/biological therapy/chemotherapy/complex therapy分类
医药卫生引用本文复制引用
刘星,张祥福,郑知文,卢辉山,吴心愿,黄昌明,王川,官国先..注射用重组改构人肿瘤坏死因子联合化疗治疗晚期恶性肿瘤的临床观察[J].中德临床肿瘤学杂志（英文版）,2005,4(3):174-178,5.
