动物学研究2001，Vol.22Issue(3)：174-180,7.
锐化蝙蝠听皮层神经元频率调谐的柱特征
Characteristics of Column Organization Sharpening Frequency
Tunings of Bat Auditory Cortical Neurons
陈其才 1PhilipH.S.JEN2
作者信息
- 1. 华中师范大学生物科学系
- 2. Divis ion of Biological Sciences,Unversity of Missouri-Columbia,
- 折叠
摘要
Abstract
98 auditory cortical (AC) neurons were obtained on the 6 big brown bats (Eptes icus fuscus) with the two-tone stimulation and multi-barrel electrode method s and the characteristics of column organization sharpening frequency tunings of AC neurons were studied.The results showed that neurons from the same orthogona l penetration had basically same inhibitory tuning curve or area at low or/and h igh limbs of excitatory tuning curve.The neurons isolated within an obliquely (4 5° with AC surface) penetrated electrode to cross multi-columns were with diff erent excitatory and inhibitory areas.Two penetrated ways of electrode demonstra ted the characteristics of column organization sharpening frequency tuning of AC neurons，in other words，AC neurons that had same function on the frequency ana lysis were with the same type of neural inhibition and they located within a sam e column forming a functional organization unit-“mini-frequency processor”.Th e multi-peaked frequency tuning curves observed in the experiment were consider ed to be essential for complex sound information processing.We can reasonably hy pothesize that AC neurons with multipeaked frequency tuning curves could execute a function as a highly tuned preprocessor of complex spectral information.In or der to investigate further the mechanism sharpening frequency tuning，GABAergic receptor-a (GABAa) antagonist，bicuculline，was injected ionophoreticaly to the AC neuron recorded through multi-barrel electrode and inhibitory areas of the neurons could be abolished mostly or completely by bicuculline application.These results showed that GABAergic inhibition participated in forming inhibitory are a of frequency tuning of AC neuron and increased the ability of frequency resolu tion under the normal physiologic condition，whereas frequency tuning curve beca me the wider and decreased the abilities of frequency selectivity and resolution after GABAergic disinhibition by bicuculline.关键词
听皮层神经元/锐化频率调谐/柱状组构/蝙蝠分类
生物科学引用本文复制引用
陈其才,PhilipH.S.JEN..锐化蝙蝠听皮层神经元频率调谐的柱特征[J].动物学研究,2001,22(3):174-180,7.
