中华医学杂志（英文版）2003，Vol.116Issue(11)：1764-1766,3.
The effect of arsenic trioxide on QT interval prolongation during APL therapy
The effect of arsenic trioxide on QT interval prolongation during APL therapy
周晋 1孟然 1李晓霞 1吕成芳 1范圣瑾 1杨宝峰2
作者信息
- 1. Department of Hematology, First Clinical College of Harbin Medical University, Harbin 150001, China
- 2. Department of Hematology, First Clinical College of Harbin Medical University, Harbin 150001, China
- 折叠
摘要
Abstract
Objective To investigate the cardiac effect of QT interval prolongation in the treatment of acute promyelocytic leukemia (APL) with arsenic trioxide (As2O3), and the relationship between QT and serum arsenic concentration.Methods Blood serum arsenic concentrations of thirty APL patients were determined at 2 hours, 4 hours, 8 hours, and 24 hours after As2O3 injection using atomic fluorophotometry. Cardiac functions were measured simultaneously using a 12-lead body-surface electrocardiogram (ECG). Q-T intervals were manually measured, and then corrected using Bazett ' s formula (QTc). QT dispersion (QTd) was also calculated. In order to assess the effects of arsenic on the symptoms of anemia, twenty-four anemia patients were divided into two groups on the basis hemoglobin concentration: Group1 (Hb≥90 g/L), and Group 2 (60 g/L≤Hb＜90 g/L). QTc and QTd of these patients were also manually measured.Results All QT intervals of APL patients treated with As2O3 injection were prolonged [32.2 ms (27, 41 ms); P< 0.05], but the changes of QTd were not prominent [3 ms (-8, 7 ms), P> 0.05]. There was a delay of 2 hours in maximum QTc following peaks in serum arsenic concentration. Changes in QTc and QTd of the two anemic groups were not prominent.Conclusions As2O3 can prolong QTc intervals in APL patients, but the effects are delayed compared to peak serum arsenic concentrations. As2O3 has no prolongation effect on QTd. Mild and moderate anemia do not effect QTc and QTd.关键词
acute promyelocytic leukemia/arsenic trioxide/electrocardiogramKey words
acute promyelocytic leukemia/arsenic trioxide/electrocardiogram分类
医药卫生引用本文复制引用
周晋,孟然,李晓霞,吕成芳,范圣瑾,杨宝峰..The effect of arsenic trioxide on QT interval prolongation during APL therapy[J].中华医学杂志（英文版）,2003,116(11):1764-1766,3.
