中国临床康复2004，Vol.8Issue(9)：1766-1767,2.
高脂血症小鼠动脉粥样硬化形成与血管内皮生长因子的关系
The relationship between vascular endothelial growth factor and atherogenesis in hyperlipidemic mice
王效杰 1齐金萍 1关宝丽1
作者信息
- 1. 沈阳医学院解剖教研室,辽宁省沈阳市,110034
- 折叠
摘要
Abstract
BACKGROUND:Long-term hyperlipidemia can promote atherogenesis and increasing attention is being drawn to the effect of various growth factors in this process.However,the effect of vascular endothelial growth factor (VEGF) remains unclear. OBJECTIVE:To study the effect of VEGF on atherogenesis. DESIGN:A randomly controlled trial study. SETTING,PARTICIPANTS and INTERVENTION:Ten female and ten male C57BL/6J mice of 8 weeks old were randomly divided into 2 groups: normal control group(NC) and atherogenic diet group(AS) with 10 mice in each.The mice in NC group were fed standard feed,while those in AS were given lipid milk prepared by us 10 mL/kg every day apart from the normal feed. MAIN OUTCOME MEASURES:Lipids(TC,TG,HDL,LDL) in serum were measured;the expression of VEGF protein in aortic wall was detected by immunohistochemical SABC method. CONCLUSION:In the condition of hyperlipidemia,endogenetic VEGF participates in thrombosis and proliferation of tunica intima and promotes the occurrence and development of atherosclerosis.关键词
高脂血症/病因学/血管内皮生长因子/免疫组织化学/小鼠分类
医药卫生引用本文复制引用
王效杰,齐金萍,关宝丽..高脂血症小鼠动脉粥样硬化形成与血管内皮生长因子的关系[J].中国临床康复,2004,8(9):1766-1767,2.
