中华医学杂志（英文版）2003，Vol.116Issue(11)：1767-1769,3.
Effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia
Effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia
黄芸 1戴闺柱 1冯宗忱 2鲁成发 3成蓓 1王秋芬 1聂福鼎 1李景东1
作者信息
- 1. Department of Cardiology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
- 2. Department of Biochemistry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- 3. Department of Ultrasound Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
- 折叠
摘要
Abstract
Objective To investigate the effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.Methods Using high-resolution ultrasound, we measured flow- and nitroglycerin-induced dilatation of the brachial artery in 30 patients with hypertriglyceridemia before and after treatment with micronized fenofibrate at a dose of 200 mg once daily for 4 weeks. Simultaneously, both serum lipid and plasma endothelin (ET) levels were determined.Results After micronized fenofibrate therapy, serum triglyceride (TG) levels decreased significantly (P<0.05). Plasma ET levels also decreased markedly [(82.66±15.46) μg/L vs. (106.22±19.16) μg/L, P<0.001]. Flow-induced vasodilatation was much improved (11.0%±9.0% vs 2.7%±2.0%, P<0.01). However, no significant changes in vasodilatation occurred in response to nitroglycerin (16.2%±6.0% vs 15.0%±5.0%, P>0.05) in patients with hypertriglyceridemia. Conclusions Micronized fenofibrate can improve impaired endothelium-dependent vasodilatation in patients with hypertriglyceridemia. Improving endothelial function may also be the mechanism responsible for the beneficial effects of micronized fenofibrate.关键词
hypertriglyceridemia/endothelium/vasodilatationKey words
hypertriglyceridemia/endothelium/vasodilatation分类
医药卫生引用本文复制引用
黄芸,戴闺柱,冯宗忱,鲁成发,成蓓,王秋芬,聂福鼎,李景东..Effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia[J].中华医学杂志（英文版）,2003,116(11):1767-1769,3.
